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KUS121, a VCP modulator, attenuates ischemic retinal cell death via suppressing endoplasmic reticulum stress

Hata M., Ikeda H.O., Kikkawa C., Iwai S., Muraoka Y., Hasegawa T., Kakizuka A., Yoshimura N.

  • 2017
  • Scientific Reports
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  • Therapeutic Area

    Back of the eye (BOTE)

  • Categories

    Preclinical development

  • Affiliations

    Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Kyoto, Japan; Neuroprotective Treatment Project for Ocular Diseases, Institute for Advancement of Clinical and Translational Science, Kyoto University Hospital, Kyoto, Japan; Pharmacology Group, Non-clinical Research, Global RandD, Santen Pharmaceutical Co., Ltd, Nara, Japan; Laboratory of Functional Biology, Kyoto Univ. Graduate School of Biostudies AndSolution Oriented Research for Science and Technology, Kyoto, Japan

Related Publications

Valosin-containing protein modulator KUS121 protects retinal neurons in a rat model of anterior ischemic optic neuropathy

Kikkawa C., Ikeda H.O., Hata M., Iwai S., Tsujikawa A.

  • 2025
  • Sci. Rep.
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Rapid and efficient generation of mature retinal organoids derived from human pluripotent stem cells via optimized pharmacological modulation of Sonic hedgehog, activin A, and retinoic acid signal transduction

Matsushita T.; Onishi A.; Matsuyama T.; Masuda T.; Ogino Y.; Kageyama M.; Takahashi M.; Uchiumi F.

  • 2024
  • PLoS ONE
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Rotenone-Induced Optic Nerve Damage and Retinal Ganglion Cell Loss in Rats

Yamamoto Y.; Taniguchi T.; Shimazaki A.

  • 2024
  • Biomolecules
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View all Back of the eye (BOTE) publications

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Document number: NP-No product-EMEA-0110
Date of preparation: February 2022

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