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Nafamostat and sepimostat identified as novel neuroprotective agents via NR2B N-methyl-D-aspartate receptor antagonism using a rat retinal excitotoxicity model

Fuwa M., Kageyama M., Ohashi K., Sasaoka M., Sato R., Tanaka M., Tashiro K.

  • 2019
  • Scientific Reports
View publication

  • Therapeutic Area

    Back of the eye (BOTE)

  • Categories

    Preclinical development

  • Affiliations

    Research and Development, Santen Pharmaceutical Co., Ltd, Nara, Japan; Global Alliances and External Research, Santen Pharmaceutical Co., Ltd, Nara, Japan; Department of Genomic Medical Sciences, Kyoto Prefectural University of Medicine, Kyoto, Japan

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Functional significance of commonly regulated genes in mechanically and chemically induced retinal ganglion cell death in rat eyes

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  • 2025
  • Sci. Rep.
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Valosin-containing protein modulator KUS121 protects retinal neurons in a rat model of anterior ischemic optic neuropathy

Kikkawa C., Ikeda H.O., Hata M., Iwai S., Tsujikawa A.

  • 2025
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Rapid and efficient generation of mature retinal organoids derived from human pluripotent stem cells via optimized pharmacological modulation of Sonic hedgehog, activin A, and retinoic acid signal transduction

Matsushita T.; Onishi A.; Matsuyama T.; Masuda T.; Ogino Y.; Kageyama M.; Takahashi M.; Uchiumi F.

  • 2024
  • PLoS ONE
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View all Back of the eye (BOTE) publications

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Document number: NP-No product-EMEA-0110
Date of preparation: February 2022

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