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The Role of EP3 Agonism in Intraocular Pressure-Lowering by Sepetaprost, a Novel Dual Agonist of FP and EP3 Receptors, in Monkeys

Maki K., Kimura E., Yamamoto Y., Fuwa M., Toris C.B., Fan S., Shimazaki A., Kato M.

  • 2025
  • Journal of Ocular Pharmacology and Therapeutics
View publication

  • Therapeutic Area

    Glaucoma

  • Categories

    Preclinical development

  • Affiliations

    Pharmaceutics and Pharmacology Department, Santen Pharmaceutical Co., Ltd., Ikoma, Nara, Japan. Department of Ophthalmology and Visual Sciences, Stanley M. Truhlsen Eye Institute, University of Nebraska Medical Center, Omaha, Nebraska, USA. Department of Ophthalmology and Visual Sciences, Havener Eye Institute, The Ohio State University College of Medicine and Wexner Medical Center, Columbus, Ohio, USA.

Related Publications

Long-term safety and efficacy of sepetaprost, with or without timolol, in patients with open-angle glaucoma or ocular hypertension: results from the randomised, phase 3 ANGEL-J2 study

Inatani M., Tone Y., Ikeda T., Angeles R.

  • 2026
  • Jpn J Ophthalmol
View publication

Efficacy and safety of sepetaprost in patients with primary open-angle glaucoma or ocular hypertension: results from the randomised, phase 3 ANGEL-J1 study

Inatani M., Kanamori A., Inai M., Ikeda T., Angeles R.

  • 2026
  • Jpn J Ophthalmol
View publication

Clinical outcomes of Preserflo MicroShunt implant procedure in open‑angle glaucoma patients – a 1000 eyes case-series; including subanalysis of combined cataract-glaucoma surgery and standalone surgery in pseudophakic eyes

Klabe, K.; Werth, J.P.; Kaymak, H. ; Fricke, A.

  • 2026
  • Graefe's Archive for Clinical and Experimental Ophthalmology
View publication
View all Glaucoma publications

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Document number: NP-No product-EMEA-0110
Date of preparation: February 2022

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