Felodipine re-positioned as a neuroprotectant via improved optic nerve head blood circulation in retinal ischemic rabbits and ocular hypertensive rats

Taniguchi T, Akaishi T, Hata T, Yamashita R, Esaki Y, Morofuji R, Okabe K, Fuwa M, Yamamoto Y, Guo L, Choi S, Luong V, Ota T, Sharif NA, Cordeiro MF, Kageyama M.

2025
Sci. Rep.

View publication

Therapeutic Area

Glaucoma
Categories

Preclinical development

Affiliations

Ophthalmology Innovation Center, Santen Pharmaceutical Co., Ltd, 8916-16 Takayama-cho, Ikoma-shi, 630 - 0101, Nara, Japan. takazumi.taniguchi@santen.com; Product Development Division, Santen Pharmaceutical Co., Ltd, Ikoma-shi, Nara, Japan; Institute of Ophthalmology, University College London (UCL), London, UK; Novai Ltd, Work Life, The White Building, 33 King's Road, Reading, RG1 3AR, UK; Ophthalmology Innovation Center, Santen Pharmaceutical Co., Ltd, 8916-16 Takayama-cho, Ikoma-shi, 630 - 0101, Nara, Japan; Ophthalmology Innovation Center, Santen Inc, Emeryville, CA, USA; Eye-APC Duke-NUS Medical School, Singapore, Singapore; Department of Pharmacy Sciences, Creighton University, Omaha, NE, USA; Department of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, Texas Southern University, Houston, TX, USA; Department of Pharmacology and Neuroscience, University of North Texas Health Sciences Center, Fort Worth, TX, USA; Singapore Eye Research Institute, Singapore, 169856, Singapore; Imperial College of Science and Technology, St. Mary's Campus, London, UK

Related Publications

Müller glia derived EVs promote neurite recovery of an enriched population of retinal ganglion like cells derived from hESC retinal organoids after damage

Eastlake K, Lamb WDB, Tracey-White D, Shibagaki K, Khaw PT, Jayaram H, Limb GA

An Exploratory Study of Machine Learning-Based Open-Angle Glaucoma Detection Using Specific Autoantibodies

Takada N., Ishikawa M., Ninomiya T., Izumi Y., Sato K., Kunikata H., Yokoyama Y., Tsuda S., Fukuda E., Yamaguchi K., Ono C., Kirihara T., Shintani C., Hanyuda A., Goshima N., Zorumski C.F., NakazawaT.

Relaxation of Precontracted Ciliary Artery and Ciliary Muscle In Vitro by Kinin Peptides: Relevance to Retinal Blood Flow and Intraocular Pressure Regulation

Sharif N.A., Kulkarni-Chitnis M., Okolie A., Chaudhry S.D., Njie-Mbye Y.F., Ohia S.E.